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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q8TBZ6

TRMT10A

Protein·UNIPROT:Q8TBZ6tRNA methyltransferase 10 homolog A

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S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs..

Function from UniProtKB (Q8TBZ6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

microcephaly, short stature, and impaired glucose metabolism 1 has a germline basis in TRMT10ADiseaseGenCC HGNC:28403|MONDO:0000208Inferred only
primary microcephaly-mild intellectual disability-young-onset diabetes syndrome has a germline basis in TRMT10ADiseaseGenCC HGNC:28403|MONDO:0018320Inferred only

Statements

3 statements

3 statements · 1 reference database · Subject: TRMT10A · Sources: Reactome

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TRMT10A participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
TRMT10A participates in tRNA modification in the nucleus and cytosolPathwayReactome R-HSA-6782315Inferred only
TRMT10A participates in tRNA processingPathwayReactome R-HSA-72306Inferred only

Reactions

1 reaction

CHEBI:74269+S-adenosyl-L-methionineCHEBI:73542+S-adenosyl-L-homocysteine+hydron
Catalysed by TRMT10B or TRMT10C or TRMT10A
Reaction pageDirection not assertedBalanced
Rhea RHEA:43156CC BY 4.0Reference data

Other names

3 names

Resolves to: TRMT10A

Also called: RG9MTD2RNA (guanine-9-)-methyltransferase domain-containing protein 2tRNA (guanine(9)-N(1))-methyltransferase TRMT10A

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