Proteins/UNIPROT:P29144

TPP2

ProteinUNIPROT:P29144

Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis. Stimulates adipogenesis (By similarity)..

Function from UniProtKB (P29144), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome has a germline basis in TPP2DiseaseGenCC HGNC:12016|MONDO:0018636Inferred only
immunodeficiency 78 with autoimmunity and developmental delay has a germline basis in TPP2DiseaseGenCC HGNC:12016|MONDO:0030971Inferred only

Statements

16 statements

16 statements · 2 reference databases · Subject: TPP2 · Sources: Hetionet, Reactome

Order

CDK2 interacts with TPP2ProteinHetionet hetionet:interacts:1017-7174Inferred only
TPP2 interacts with SIRT7ProteinHetionet hetionet:interacts:51547-7174Inferred only
TPP2 interacts with UBCProteinHetionet hetionet:interacts:7174-7316Inferred only
TPP2 interacts with UBDProteinHetionet hetionet:interacts:10537-7174Inferred only
TPP2 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
TPP2 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
TPP2 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
TPP2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CLTB increases the expression of TPP2ProteinHetionet hetionet:regulates:1212-7174Inferred only
LMO4 increases the expression of TPP2ProteinHetionet hetionet:regulates:8543-7174Inferred only
MCM7 increases the expression of TPP2ProteinHetionet hetionet:regulates:4176-7174Inferred only
PABPC1 increases the expression of TPP2ProteinHetionet hetionet:regulates:26986-7174Inferred only

Show the remaining 4

RPS19 increases the expression of TPP2ProteinHetionet hetionet:regulates:6223-7174Inferred only
SLC35A3 increases the expression of TPP2ProteinHetionet hetionet:regulates:23443-7174Inferred only
SMC1A decreases the expression of TPP2ProteinHetionet hetionet:regulates:8243-7174Inferred only
TM9SF2 decreases the expression of TPP2ProteinHetionet hetionet:regulates:9375-7174Inferred only

Other names

4 names

Resolves to: TPP2

Also called: TPP-2TPP-IITripeptidyl aminopeptidaseTripeptidyl-peptidase II

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