TNRC18

Chromatin reader involved in the silencing of endogenous retroviruses (ERV) class-I elements, such as LTR12. Specifically binds histone H3 trimethylated at 'Lys-9' (H3K9me3) deposited by SETB1 at class-I ERV and directly mediates recruitment of corepressor complexes, such as Sin3-type and N-Cor complexes, leading to ERV silencing..

Function from UniProtKB (O15417), read 2026-09-23. CC BY 4.0.