Proteins/UNIPROT:O14798

TNFRSF10C

ProteinUNIPROT:O14798

Acts as a receptor for the cytotoxic ligand TRAIL but does not contain the intracellular death domain required to initiate apoptosis. By competing with the functional TRAIL receptors TNFRSF10A and TNFRSF10B for ligand binding, it functions as a decoy receptor that protects cells from TRAIL-induced apoptosis..

Function from UniProtKB (O14798), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 3 reference databases · Subject: TNFRSF10C · Sources: Hetionet, Reactome, WikiPathways

Order

APOA1 interacts with TNFRSF10CProteinHetionet hetionet:interacts:335-8794Inferred only
TNFRSF10C interacts with LRSAM1ProteinHetionet hetionet:interacts:8794-90678Inferred only
RAP1A interacts with TNFRSF10CProteinHetionet hetionet:interacts:5906-8794Inferred only
TNFRSF10C interacts with RFLNBProteinHetionet hetionet:interacts:359845-8794Inferred only
TNFRSF10C interacts with SLC27A6ProteinHetionet hetionet:interacts:28965-8794Inferred only
TNFSF10 interacts with TNFRSF10CProteinHetionet hetionet:interacts:8743-8794Inferred only
TNFRSF10C interacts with ZHX1ProteinHetionet hetionet:interacts:11244-8794Inferred only
TNFRSF10C participates in Apoptosis modulation and signalingPathwayWikiPathways WP1772Inferred only
TNFRSF10C participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
TNFRSF10C participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
TNFRSF10C participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
TNFRSF10C participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only

Show the remaining 7

TNFRSF10C participates in TP53 Regulates Transcription of Cell Death GenesPathwayReactome R-HSA-5633008Inferred only
TNFRSF10C participates in TP53 Regulates Transcription of Death Receptors and LigandsPathwayReactome R-HSA-6803211Inferred only
TNFRSF10C participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
TNFRSF10C participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
BAG3 increases the expression of TNFRSF10CProteinHetionet hetionet:regulates:9531-8794Inferred only
CASP3 increases the expression of TNFRSF10CProteinHetionet hetionet:regulates:836-8794Inferred only
CCP110 increases the expression of TNFRSF10CProteinHetionet hetionet:regulates:9738-8794Inferred only

Other names

13 names

Resolves to: TNFRSF10C

Also called: Antagonist decoy receptor for TRAIL/Apo-2LCD antigen CD263DCR1Decoy receptor 1Decoy TRAIL receptor without death domainLITLymphocyte inhibitor of TRAILTNF-related apoptosis-inducing ligand receptor 3TRAIL receptor 3TRAIL receptor without an intracellular domainTRAIL-R3TRAILR3TRID

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