Proteins/UNIPROT:Q8IU68

TMC8

ProteinUNIPROT:Q8IU68

Acts as a regulatory protein involved in the regulation of numerous cellular processes. Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally. Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER. Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels. Down-regulates the activity of transcription factors induced by zinc and cytokines. Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions..

Function from UniProtKB (Q8IU68), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

epidermodysplasia verruciformis has a germline basis in TMC8DiseaseGenCC HGNC:20474|MONDO:0009176Inferred only
epidermodysplasia verruciformis, susceptibility to, 2 has a germline basis in TMC8DiseaseGenCC HGNC:20474|MONDO:0032614Inferred only

Statements

7 statements

7 statements · 2 reference databases · Subject: TMC8 · Sources: gene ontology, Hetionet

Order

IL17REL covaries with TMC8ProteinHetionet hetionet:covaries:147138-400935Inferred only
TMC8 regulates negative regulation of canonical NF-kappaB signal transductionBiological processgene ontology Q8IU68|GO:0043124Inferred only
TMC8 regulates negative regulation of protein bindingBiological processgene ontology Q8IU68|GO:0032091Inferred only
TMC8 regulates negative regulation of protein-containing complex assemblyBiological processgene ontology Q8IU68|GO:0031333Inferred only
TMC8 regulates positive regulation of apoptotic processBiological processgene ontology Q8IU68|GO:0043065Inferred only
TMC8 regulates regulation of extrinsic apoptotic signaling pathway via death domain receptorsBiological processgene ontology Q8IU68|GO:1902041Inferred only
TMC8 regulates regulation of tumor necrosis factor-mediated signaling pathwayBiological processgene ontology Q8IU68|GO:0010803Inferred only

Other names

4 names

Resolves to: TMC8

Also called: Epidermodysplasia verruciformis protein 2EVER2EVIN2Transmembrane channel-like protein 8

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