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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:O43897

TLL1

Protein·UNIPROT:O43897

Open in the graph

Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.

Function from UniProtKB (O43897), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

atrial septal defect 6 has a germline basis in TLL1DiseaseGenCC HGNC:11843|MONDO:0013123Inferred only

Statements

10 statements

10 statements · 3 reference databases · Subject: TLL1 · Sources: Hetionet, Reactome, UniProt

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APP interacts with TLL1ProteinHetionet hetionet:interacts:351-7092Inferred only
TLL1 interacts with UBCProteinHetionet hetionet:interacts:7092-7316Inferred only
TLL1 participates in Anchoring fibril formationPathwayReactome R-HSA-2214320Inferred only
TLL1 participates in Assembly of collagen fibrils and other multimeric structuresPathwayReactome R-HSA-2022090Inferred only
TLL1 participates in Collagen biosynthesis and modifying enzymesPathwayReactome R-HSA-1650814Inferred only
TLL1 participates in Collagen formationPathwayReactome R-HSA-1474290Inferred only
TLL1 participates in Crosslinking of collagen fibrilsPathwayReactome R-HSA-2243919Inferred only
TLL1 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
TLL1 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
TLL1 requires the cofactor Zn(2+)CompoundUniProt O43897Inferred only

Other names

2 names

Resolves to: TLL1

Also called: TLLTolloid-like protein 1

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