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Proteins/UNIPROT:Q6N021
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT..
Function from UniProtKB (Q6N021), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
22 statements
22 statements · 5 reference databases · Subject: TET2 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
3 reactions
a 5-methyl-2'-deoxycytidine in DNA+2-oxoglutarate(2-)+dioxygena 5-hydroxymethyl-2'-deoxycytidine in DNA+succinate(2-)+carbon dioxide
Catalysed by TET3 or TET2 or TET1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52636CC BY 4.0Reference data
a 5-hydroxymethyl-2'-deoxycytidine in DNA+2-oxoglutarate(2-)+dioxygena 5-formyl-2'-deoxycytidine in DNA
2 names
Resolves to: TET2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53828CC BY 4.0Reference data
a 5-formyl-2'-deoxycytidine in DNA+2-oxoglutarate(2-)+dioxygena 5-carboxyl-2'-deoxycytidine in DNA+succinate(2-)+carbon dioxide+hydron
Catalysed by TET3 or TET2 or TET1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53832CC BY 4.0Reference data