Proteins/UNIPROT:Q96S53

TESK2

ProteinUNIPROT:Q96S53

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.

Function from UniProtKB (Q96S53), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 3 reference databases · Subject: TESK2 · Sources: Hetionet, UniProt, WikiPathways

Order

CFL1 interacts with TESK2ProteinHetionet hetionet:interacts:10420-1072Inferred only
TESK2 interacts with DSTNProteinHetionet hetionet:interacts:10420-11034Inferred only
HSP90AA1 interacts with TESK2ProteinHetionet hetionet:interacts:10420-3320Inferred only
HSP90AB1 interacts with TESK2ProteinHetionet hetionet:interacts:10420-3326Inferred only
YWHAB interacts with TESK2ProteinHetionet hetionet:interacts:10420-7529Inferred only
TESK2 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
TESK2 participates in Microtubule cytoskeleton regulationPathwayWikiPathways WP2038Inferred only
TESK2 decreases the expression of COG2ProteinHetionet hetionet:regulates:10420-22796Inferred only
TESK2 decreases the expression of EXT1ProteinHetionet hetionet:regulates:10420-2131Inferred only
TESK2 increases the expression of GNAI1ProteinHetionet hetionet:regulates:10420-2770Inferred only
TESK2 increases the expression of JADE2ProteinHetionet hetionet:regulates:10420-23338Inferred only
TESK2 increases the expression of LYNProteinHetionet hetionet:regulates:10420-4067Inferred only

Show the remaining 9

TESK2 decreases the expression of PCCBProteinHetionet hetionet:regulates:10420-5096Inferred only
TESK2 decreases the expression of PCNAProteinHetionet hetionet:regulates:10420-5111Inferred only
TESK2 increases the expression of PIGBProteinHetionet hetionet:regulates:10420-9488Inferred only
TESK2 increases the expression of RRS1ProteinHetionet hetionet:regulates:10420-23212Inferred only
TESK2 increases the expression of SFNProteinHetionet hetionet:regulates:10420-2810Inferred only
TESK2 decreases the expression of TXNDC9ProteinHetionet hetionet:regulates:10420-10190Inferred only
TESK2 increases the expression of WIF1ProteinHetionet hetionet:regulates:10420-11197Inferred only
TESK2 requires the cofactor magnesium(2+)CompoundUniProt Q96S53Inferred only
TESK2 requires the cofactor Mn(2+)CompoundUniProt Q96S53Inferred only

Reactions

3 reactions

L-tyrosyl-[protein]+ATP(4-)O-phospho-L-tyrosyl-[protein]+ADP(3-)+hydron
Catalysed by MAP2K7 or MUSK or RIPK2 or DYRK3 or JAK2 or STK16 or ABL1 or EGFR or ERBB2 or NTRK1 or INSR or LCK and 104 more alternatives
Reaction page

Other names

1 name

Resolves to: TESK2

Also called: Testicular protein kinase 2

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