Proteins/UNIPROT:Q96GX1

TCTN2

ProteinUNIPROT:Q96GX1

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity)..

Function from UniProtKB (Q96GX1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

Joubert syndrome has a germline basis in TCTN2DiseaseGenCC HGNC:25774|MONDO:0018772Inferred only
Joubert syndrome 24 has a germline basis in TCTN2DiseaseGenCC HGNC:25774|MONDO:0014724Inferred only
Meckel syndrome has a germline basis in TCTN2DiseaseGenCC HGNC:25774|MONDO:0018921Inferred only
Meckel syndrome, type 8 has a germline basis in TCTN2DiseaseGenCC HGNC:25774|MONDO:0013482Inferred only

Statements

19 statements

19 statements · 3 reference databases · Subject: TCTN2 · Sources: Hetionet, Reactome, WikiPathways

Order

ACD covaries with TCTN2ProteinHetionet hetionet:covaries:65057-79867Inferred only
MYO9B covaries with TCTN2ProteinHetionet hetionet:covaries:4650-79867Inferred only
OR2G2 covaries with TCTN2ProteinHetionet hetionet:covaries:79867-81470Inferred only
TCTN2 covaries with OTUD1ProteinHetionet hetionet:covaries:220213-79867Inferred only
TCEAL4 covaries with TCTN2ProteinHetionet hetionet:covaries:79867-79921Inferred only
TCTN2 covaries with ZFP69BProteinHetionet hetionet:covaries:65243-79867Inferred only
UBC interacts with TCTN2ProteinHetionet hetionet:interacts:7316-79867Inferred only
TCTN2 participates in Anchoring of the basal body to the plasma membranePathwayReactome R-HSA-5620912Inferred only
TCTN2 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
TCTN2 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
TCTN2 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
TCTN2 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only

Show the remaining 7

TCTN2 participates in Joubert syndromePathwayWikiPathways WP4656Inferred only
TCTN2 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
CASP3 decreases the expression of TCTN2ProteinHetionet hetionet:regulates:836-79867Inferred only
GALE increases the expression of TCTN2ProteinHetionet hetionet:regulates:2582-79867Inferred only
NMT1 decreases the expression of TCTN2ProteinHetionet hetionet:regulates:4836-79867Inferred only
POLR2F decreases the expression of TCTN2ProteinHetionet hetionet:regulates:5435-79867Inferred only
RFC2 decreases the expression of TCTN2ProteinHetionet hetionet:regulates:5982-79867Inferred only

Other names

3 names

Resolves to: TCTN2

Also called: C12orf38TECT2Tectonic-2

← Every protein Find it in the graph →