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Proteins/UNIPROT:A2RTX5

TARS3

Protein·UNIPROT:A2RTX5Threonine--tRNA ligase 2, cytoplasmic

Open in the graph

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage..

Function from UniProtKB (A2RTX5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

33 statements

33 statements · 4 reference databases · Subject: TARS3 · Sources: Bgee, Hetionet, Human Protein Atlas, Rhea

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TARS3 is expressed in adrenal glandAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in Ammon's hornAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in bone marrowAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in breastAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in caudate nucleusAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in cerebellumAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in cerebral cortexAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in colonAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in corpus callosumAnatomyBgee ENSG00000185418Inferred only
TARS3 is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in endometriumAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in fallopian tubeAnatomyHuman Protein Atlas ENSG00000185418Inferred only

Show the remaining 21

TARS3 is expressed in lymph nodeAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in myocardiumAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in pancreasAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in parathyroid glandAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in rectumAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in seminal vesicleAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in Skeletal muscle tissueAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in smooth muscle tissueAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in spleenAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in stomachAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in testisAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in thyroid glandAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in tonsilAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in vastus lateralisAnatomyBgee ENSG00000185418Inferred only
TARS3 is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000185418Inferred only
TARS3 is expressed in zone of skinAnatomyHuman Protein Atlas ENSG00000185418Inferred only
PRKAB1 interacts with TARS3ProteinHetionet hetionet:interacts:123283-5564Inferred only
TRAF6 interacts with TARS3ProteinHetionet hetionet:interacts:123283-7189Inferred only
UBC interacts with TARS3ProteinHetionet hetionet:interacts:123283-7316Inferred only
L-threonine is a substrate of TARS3CompoundRhea RHEA:24624Inferred only

Reactions

1 reaction

CHEBI:78442+L-threonine+ATP(4-)CHEBI:78534+AMP+diphosphate(3-)+hydron
Catalysed by TARS3 or TARS1 or TARS2
Reaction pageDirection not assertedBalanced
Rhea RHEA:24624CC BY 4.0Reference data

Other names

4 names

Resolves to: TARS3

Also called: TARSL2Threonyl-tRNA synthetaseThreonyl-tRNA synthetase protein 3ThrRS

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