Proteins/UNIPROT:Q9P289

STK26

ProteinUNIPROT:Q9P289

Serine/threonine-protein kinase that acts as a mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation..

Function from UniProtKB (Q9P289), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 4 reference databases · Subject: STK26 · Sources: gene ontology, Hetionet, Reactome, UniProt

Order

STK26 covaries with OR51G2ProteinHetionet hetionet:covaries:51765-81282Inferred only
STK26 covaries with PTGER1ProteinHetionet hetionet:covaries:51765-5731Inferred only
STK26 covaries with R3HDM4ProteinHetionet hetionet:covaries:51765-91300Inferred only
STK26 participates in ApoptosisPathwayReactome R-HSA-109581Inferred only
STK26 participates in Apoptotic cleavage of cellular proteinsPathwayReactome R-HSA-111465Inferred only
STK26 participates in Apoptotic execution phasePathwayReactome R-HSA-75153Inferred only
STK26 participates in Programmed Cell DeathPathwayReactome R-HSA-5357801Inferred only
STK26 regulates negative regulation of cell migrationBiological processgene ontology Q9P289|GO:0030336Inferred only
STK26 regulates positive regulation of microvillus assemblyBiological processgene ontology Q9P289|GO:1903698Inferred only
STK26 regulates regulation of apoptotic processBiological processgene ontology Q9P289|GO:0042981Inferred only
EP300 increases the expression of STK26ProteinHetionet hetionet:regulates:2033-51765Inferred only
PHKB decreases the expression of STK26ProteinHetionet hetionet:regulates:5257-51765Inferred only

Show the remaining 1

STK26 requires the cofactor magnesium(2+)CompoundUniProt Q9P289Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

7 names

Resolves to: STK26

Also called: Mammalian STE20-like protein kinase 4MASKMST-4MST3 and SOK1-related kinaseMST4Serine/threonine-protein kinase MASKSTE20-like kinase MST4

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