SPIDR

Involved in early stages DNA double-strand break (DSB) repair via homologous recombination (HR). As part of the Shu complex, promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA. The Shu complex is essential during meiosis by stabilizing DMC1 filaments. In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid..

Function from UniProtKB (Q14159), read 2026-09-23. CC BY 4.0.