Proteins/UNIPROT:Q9H0W8

SMG9

ProteinUNIPROT:Q9H0W8

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. Plays a role in brain, heart, and eye development (By similarity)..

Function from UniProtKB (Q9H0W8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

heart and brain malformation syndrome has a germline basis in SMG9DiseaseGenCC HGNC:25763|MONDO:0014833Inferred only

Statements

13 statements

13 statements · 3 reference databases · Subject: SMG9 · Sources: gene ontology, Hetionet, Reactome

Order

SMG9 covaries with ANTKMTProteinHetionet hetionet:covaries:56006-65990Inferred only
NLRP12 covaries with SMG9ProteinHetionet hetionet:covaries:56006-91662Inferred only
ZBED2 covaries with SMG9ProteinHetionet hetionet:covaries:56006-79413Inferred only
ZNF157 covaries with SMG9ProteinHetionet hetionet:covaries:56006-7712Inferred only
ZNF432 covaries with SMG9ProteinHetionet hetionet:covaries:56006-9668Inferred only
SMG1 interacts with SMG9ProteinHetionet hetionet:interacts:23049-56006Inferred only
SMG8 interacts with SMG9ProteinHetionet hetionet:interacts:55181-56006Inferred only
UBC interacts with SMG9ProteinHetionet hetionet:interacts:56006-7316Inferred only
SMG9 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
SMG9 participates in Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)PathwayReactome R-HSA-975957Inferred only
SMG9 participates in Nonsense-Mediated Decay (NMD)PathwayReactome R-HSA-927802Inferred only
SMG9 regulates negative regulation of apoptotic processBiological processgene ontology Q9H0W8|GO:0043066Inferred only

Show the remaining 1

SMG9 regulates regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decayBiological processgene ontology Q9H0W8|GO:2000622Inferred only

Other names

2 names

Resolves to: SMG9

Also called: C19orf61Nonsense-mediated mRNA decay factor SMG9

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