Proteins/UNIPROT:Q9NZC9

SMARCAL1

ProteinUNIPROT:Q9NZC9

ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks..

Function from UniProtKB (Q9NZC9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Schimke immuno-osseous dysplasia has a germline basis in SMARCAL1DiseaseGenCC HGNC:11102|MONDO:0009458Inferred only

Statements

9 statements

9 statements · 3 reference databases · Subject: SMARCAL1 · Sources: gene ontology, Hetionet, WikiPathways

Order

UBC interacts with SMARCAL1ProteinHetionet hetionet:interacts:50485-7316Inferred only
SMARCAL1 participates in DNA IR damage and cellular response via ATRPathwayWikiPathways WP4016Inferred only
SMARCAL1 participates in Nephrotic syndromePathwayWikiPathways WP4758Inferred only
SMARCAL1 participates in Primary focal segmental glomerulosclerosis FSGS PathwayWikiPathways WP2572Inferred only
SMARCAL1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9NZC9|GO:0006357Inferred only
CSK decreases the expression of SMARCAL1ProteinHetionet hetionet:regulates:1445-50485Inferred only
DGKD increases the expression of SMARCAL1ProteinHetionet hetionet:regulates:8527-50485Inferred only
EBF1 decreases the expression of SMARCAL1ProteinHetionet hetionet:regulates:1879-50485Inferred only
RNF167 increases the expression of SMARCAL1ProteinHetionet hetionet:regulates:26001-50485Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

5 names

Resolves to: SMARCAL1

Also called: HARPHepA-related proteinhHARPSucrose nonfermenting protein 2-like 1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

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