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Proteins/UNIPROT:Q8IW03

SIAH3

Protein·UNIPROT:Q8IW03

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Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria..

Function from UniProtKB (Q8IW03), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

3 statements

3 statements · 2 reference databases · Subject: SIAH3 · Sources: gene ontology, Hetionet

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PSCA covaries with SIAH3ProteinHetionet hetionet:covaries:283514-8000Inferred only
SIAH3 regulates negative regulation of protein localization to mitochondrionBiological processgene ontology Q8IW03|GO:1903748Inferred only
SIAH3 regulates regulation of protein stabilityBiological processgene ontology Q8IW03|GO:0031647Inferred only

Other names

2 names

Resolves to: SIAH3

Also called: Seven in absentia homolog 3Siah-3

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