Proteins/UNIPROT:O14492

SH2B2

ProteinUNIPROT:O14492

Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3..

Function from UniProtKB (O14492), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

29 statements

29 statements · 3 reference databases · Subject: SH2B2 · Sources: Hetionet, Reactome, WikiPathways

Order

SH2B2 covaries with COMPProteinHetionet hetionet:covaries:10603-1311Inferred only
SH2B2 covaries with KCNK3ProteinHetionet hetionet:covaries:10603-3777Inferred only
AKT1 interacts with SH2B2ProteinHetionet hetionet:interacts:10603-207Inferred only
SH2B2 interacts with ASB6ProteinHetionet hetionet:interacts:10603-140459Inferred only
BTK interacts with SH2B2ProteinHetionet hetionet:interacts:10603-695Inferred only
CBL interacts with SH2B2ProteinHetionet hetionet:interacts:10603-867Inferred only
EPOR interacts with SH2B2ProteinHetionet hetionet:interacts:10603-2057Inferred only
GRB2 interacts with SH2B2ProteinHetionet hetionet:interacts:10603-2885Inferred only
INSR interacts with SH2B2ProteinHetionet hetionet:interacts:10603-3643Inferred only
JAK1 interacts with SH2B2ProteinHetionet hetionet:interacts:10603-3716Inferred only
JAK2 interacts with SH2B2ProteinHetionet hetionet:interacts:10603-3717Inferred only
JAK3 interacts with SH2B2ProteinHetionet hetionet:interacts:10603-3718Inferred only

Show the remaining 17

KIT interacts with SH2B2ProteinHetionet hetionet:interacts:10603-3815Inferred only
LYN interacts with SH2B2ProteinHetionet hetionet:interacts:10603-4067Inferred only
NTRK1 interacts with SH2B2ProteinHetionet hetionet:interacts:10603-4914Inferred only
NTRK2 interacts with SH2B2ProteinHetionet hetionet:interacts:10603-4915Inferred only
SHC1 interacts with SH2B2ProteinHetionet hetionet:interacts:10603-6464Inferred only
SORBS1 interacts with SH2B2ProteinHetionet hetionet:interacts:10580-10603Inferred only
SYK interacts with SH2B2ProteinHetionet hetionet:interacts:10603-6850Inferred only
SH2B2 participates in BDNF signaling in neurodevelopmentPathwayWikiPathways WP5541Inferred only
SH2B2 participates in Brain derived neurotrophic factor BDNF signalingPathwayWikiPathways WP2380Inferred only
SH2B2 participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
SH2B2 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
SH2B2 participates in Insulin signalingPathwayWikiPathways WP481Inferred only
SH2B2 participates in Kit receptor signalingPathwayWikiPathways WP304Inferred only
SH2B2 participates in Regulation of KIT signalingPathwayReactome R-HSA-1433559Inferred only
SH2B2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SH2B2 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
SH2B2 participates in Signaling by SCF-KITPathwayReactome R-HSA-1433557Inferred only

Other names

3 names

Resolves to: SH2B2

Also called: Adapter protein with pleckstrin homology and Src homology 2 domainsAPSSH2 and PH domain-containing adapter protein APS

← Every protein Find it in the graph →