Proteins/UNIPROT:O43556

SGCE

ProteinUNIPROT:O43556

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Function from UniProtKB (O43556), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

myoclonic dystonia 11 has a germline basis in SGCEDiseaseGenCC HGNC:10808|MONDO:0008044Inferred only
myoclonus-dystonia syndrome has a germline basis in SGCEDiseaseGenCC HGNC:10808|MONDO:0000903Inferred only

Statements

15 statements

15 statements · 2 reference databases · Subject: SGCE · Sources: Hetionet, Reactome

Order

SGCE covaries with NR4A1ProteinHetionet hetionet:covaries:3164-8910Inferred only
SGCE interacts with ARIH2ProteinHetionet hetionet:interacts:10425-8910Inferred only
SGCE interacts with CWC15ProteinHetionet hetionet:interacts:51503-8910Inferred only
PPP1CC interacts with SGCEProteinHetionet hetionet:interacts:5501-8910Inferred only
UBC interacts with SGCEProteinHetionet hetionet:interacts:7316-8910Inferred only
SGCE participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
SGCE participates in Formation of the dystrophin-glycoprotein complex (DGC)PathwayReactome R-HSA-9913351Inferred only
SGCE participates in Non-integrin membrane-ECM interactionsPathwayReactome R-HSA-3000171Inferred only
CTSK decreases the expression of SGCEProteinHetionet hetionet:regulates:1513-8910Inferred only
EGFR increases the expression of SGCEProteinHetionet hetionet:regulates:1956-8910Inferred only
EGR1 decreases the expression of SGCEProteinHetionet hetionet:regulates:1958-8910Inferred only
HIF1AN increases the expression of SGCEProteinHetionet hetionet:regulates:55662-8910Inferred only

Show the remaining 3

SUZ12 increases the expression of SGCEProteinHetionet hetionet:regulates:23512-8910Inferred only
USF1 decreases the expression of SGCEProteinHetionet hetionet:regulates:7391-8910Inferred only
XRCC4 decreases the expression of SGCEProteinHetionet hetionet:regulates:7518-8910Inferred only

Other names

3 names

Resolves to: SGCE

Also called: Epsilon-sarcoglycanEpsilon-SGESG

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