Proteins/UNIPROT:Q6FHJ7

SFRP4

ProteinUNIPROT:Q6FHJ7

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake..

Function from UniProtKB (Q6FHJ7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Pyle disease has a germline basis in SFRP4DiseaseGenCC HGNC:10778|MONDO:0009943Inferred only

Statements

26 statements

26 statements · 3 reference databases · Subject: SFRP4 · Sources: gene ontology, Hetionet, WikiPathways

Order

EPOP covaries with SFRP4ProteinHetionet hetionet:covaries:100170841-6424Inferred only
RASSF10 covaries with SFRP4ProteinHetionet hetionet:covaries:6424-644943Inferred only
SFRP4 covaries with WNT7BProteinHetionet hetionet:covaries:6424-7477Inferred only
SFRP4 participates in AdipogenesisPathwayWikiPathways WP236Inferred only
SFRP4 participates in Alzheimer 39 s diseasePathwayWikiPathways WP5124Inferred only
SFRP4 participates in Alzheimer 39 s disease and miRNA effectsPathwayWikiPathways WP2059Inferred only
SFRP4 participates in Breast cancer pathwayPathwayWikiPathways WP4262Inferred only
SFRP4 participates in lncRNA in canonical Wnt signaling and colorectal cancerPathwayWikiPathways WP4258Inferred only
SFRP4 participates in ncRNAs in Wnt signaling in hepatocellular carcinomaPathwayWikiPathways WP4336Inferred only
SFRP4 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
SFRP4 participates in Polycystic kidney disease pathwayPathwayWikiPathways WP2571Inferred only
SFRP4 participates in Regulation of Wnt B catenin signaling by small molecule compoundsPathwayWikiPathways WP3664Inferred only

Show the remaining 14

SFRP4 participates in Wnt signalingPathwayWikiPathways WP428Inferred only
SFRP4 regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q6FHJ7|GO:0090090Inferred only
SFRP4 regulates negative regulation of cell population proliferationBiological processgene ontology Q6FHJ7|GO:0008285Inferred only
SFRP4 regulates negative regulation of non-canonical Wnt signaling pathwayBiological processgene ontology Q6FHJ7|GO:2000051Inferred only
SFRP4 regulates negative regulation of sodium-dependent phosphate transportBiological processgene ontology Q6FHJ7|GO:2000119Inferred only
SFRP4 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q6FHJ7|GO:0000122Inferred only
SFRP4 regulates negative regulation of Wnt signaling pathwayBiological processgene ontology Q6FHJ7|GO:0030178Inferred only
SFRP4 regulates positive regulation of apoptotic processBiological processgene ontology Q6FHJ7|GO:0043065Inferred only
SFRP4 regulates positive regulation of canonical Wnt signaling pathwayBiological processgene ontology Q6FHJ7|GO:0090263Inferred only
SFRP4 regulates positive regulation of epidermal cell differentiationBiological processgene ontology Q6FHJ7|GO:0045606Inferred only
SFRP4 regulates positive regulation of gene expressionBiological processgene ontology Q6FHJ7|GO:0010628Inferred only
SFRP4 regulates positive regulation of keratinocyte apoptotic processBiological processgene ontology Q6FHJ7|GO:1902174Inferred only
SFRP4 regulates positive regulation of receptor internalizationBiological processgene ontology Q6FHJ7|GO:0002092Inferred only
SFRP4 regulates regulation of BMP signaling pathwayBiological processgene ontology Q6FHJ7|GO:0030510Inferred only

Other names

3 names

Resolves to: SFRP4

Also called: Frizzled protein, human endometriumFRPHEsFRP-4

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