Proteins/UNIPROT:Q14140

SERTAD2

ProteinUNIPROT:Q14140

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism..

Function from UniProtKB (Q14140), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 3 reference databases · Subject: SERTAD2 · Sources: gene ontology, Hetionet, WikiPathways

Order

E2F1 interacts with SERTAD2ProteinHetionet hetionet:interacts:1869-9792Inferred only
KAT2B interacts with SERTAD2ProteinHetionet hetionet:interacts:8850-9792Inferred only
SERTAD2 interacts with SUPT7LProteinHetionet hetionet:interacts:9792-9913Inferred only
TFDP1 interacts with SERTAD2ProteinHetionet hetionet:interacts:7027-9792Inferred only
SERTAD2 interacts with TRIM28ProteinHetionet hetionet:interacts:10155-9792Inferred only
UBC interacts with SERTAD2ProteinHetionet hetionet:interacts:7316-9792Inferred only
XPO1 interacts with SERTAD2ProteinHetionet hetionet:interacts:7514-9792Inferred only
SERTAD2 participates in Glucocorticoid receptor pathwayPathwayWikiPathways WP2880Inferred only
SERTAD2 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
SERTAD2 regulates negative regulation of cell growthBiological processgene ontology Q14140|GO:0030308Inferred only
DDX42 increases the expression of SERTAD2ProteinHetionet hetionet:regulates:11325-9792Inferred only
FGG increases the expression of SERTAD2ProteinHetionet hetionet:regulates:2266-9792Inferred only

Show the remaining 8

HMGB1 increases the expression of SERTAD2ProteinHetionet hetionet:regulates:3146-9792Inferred only
LASP1 increases the expression of SERTAD2ProteinHetionet hetionet:regulates:3927-9792Inferred only
MLEC increases the expression of SERTAD2ProteinHetionet hetionet:regulates:9761-9792Inferred only
NOTCH2NLA increases the expression of SERTAD2ProteinHetionet hetionet:regulates:388677-9792Inferred only
NUDT9 increases the expression of SERTAD2ProteinHetionet hetionet:regulates:53343-9792Inferred only
SMARCE1 increases the expression of SERTAD2ProteinHetionet hetionet:regulates:6605-9792Inferred only
THADA increases the expression of SERTAD2ProteinHetionet hetionet:regulates:63892-9792Inferred only
WARS2 increases the expression of SERTAD2ProteinHetionet hetionet:regulates:10352-9792Inferred only

Other names

4 names

Resolves to: SERTAD2

Also called: KIAA0127Transcriptional regulator interacting with the PHD-bromodomain 2TRIP-Br2TRIPBR2

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