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Proteins/UNIPROT:O15041

SEMA3E

Protein·UNIPROT:O15041

Open in the graph

Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity)..

Function from UniProtKB (O15041), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

CHD7-related CHARGE syndrome has a germline basis in SEMA3EDiseaseGenCC HGNC:10727|MONDO:1010178Inferred only

Statements

11 statements

11 statements · 2 reference databases · Subject: SEMA3E · Sources: gene ontology, Reactome

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SEMA3E participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
SEMA3E participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SEMA3E participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
SEMA3E participates in Other semaphorin interactionsPathwayReactome R-HSA-416700Inferred only
SEMA3E participates in Semaphorin interactionsPathwayReactome R-HSA-373755Inferred only
SEMA3E regulates negative regulation of angiogenesisBiological processgene ontology O15041|GO:0016525Inferred only
SEMA3E regulates negative regulation of cell-matrix adhesionBiological processgene ontology O15041|GO:0001953Inferred only
SEMA3E regulates negative regulation of neuron apoptotic processBiological processgene ontology O15041|GO:0043524Inferred only
SEMA3E regulates positive regulation of cell migrationBiological processgene ontology O15041|GO:0030335Inferred only
SEMA3E regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology O15041|GO:0051897Inferred only
SEMA3E regulates regulation of cell shapeBiological processgene ontology O15041|GO:0008360Inferred only

Other names

3 names

Resolves to: SEMA3E

Also called: KIAA0331SEMAHSemaphorin-3E

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