Proteins/UNIPROT:Q7Z3H4

SAMD7

ProteinUNIPROT:Q7Z3H4

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells. Via its association with the PRC1-like complex, promotes epigenetic repressive marks H3K27me3 and H2AK119ub marks in nonrod genes, silencing their transcription. Represses Crx-controlled photoreceptor-specific gene expression..

Function from UniProtKB (Q7Z3H4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

macular dystrophy with or without cone dysfunction has a germline basis in SAMD7DiseaseGenCC HGNC:25394|MONDO:0958326Inferred only

Statements

3 statements

3 statements · 2 reference databases · Subject: SAMD7 · Sources: gene ontology, Hetionet

Order

SAMD7 covaries with GET1ProteinHetionet hetionet:covaries:344658-7485Inferred only
SAMD7 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q7Z3H4|GO:0045892Inferred only
SAMD7 regulates negative regulation of gene expression, epigeneticBiological processgene ontology Q7Z3H4|GO:0045814Inferred only

Other names

2 names

Resolves to: SAMD7

Also called: SAM domain-containing protein 7Sterile alpha motif domain-containing protein 7

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