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Proteins/UNIPROT:P10523

SAG

Protein·UNIPROT:P10523

Open in the graph

Involved in the regulation of phototransduction, playing a key role in signal termination after rhodopsin (RHO) has been activated by light in rod photoreceptors. Binds to photoactivated and phosphorylated RHO, preventing its interaction with transducin (GNAT1) and terminating transducin-mediated opsin signaling (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells..

Function from UniProtKB (P10523), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

6 rows

Oguchi disease has a germline basis in SAGDiseaseGenCC HGNC:10521|MONDO:0019152Inferred only
Oguchi disease-1 has a germline basis in SAGDiseaseGenCC HGNC:10521|MONDO:0009775Inferred only
retinal disorder has a germline basis in SAGDiseaseGenCC HGNC:10521|MONDO:0005283Inferred only
retinitis pigmentosa has a germline basis in SAGDiseaseGenCC HGNC:10521|MONDO:0019200Inferred only
retinitis pigmentosa 47 has a germline basis in SAGDiseaseGenCC HGNC:10521|MONDO:0013407Inferred only
retinitis pigmentosa 96 has a germline basis in SAGDiseaseGenCC HGNC:10521|MONDO:0859367Inferred only

Statements

9 statements

9 statements · 2 reference databases · Subject: SAG · Sources: Hetionet, Reactome

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ADRA1B interacts with SAGProteinHetionet hetionet:interacts:147-6295Inferred only
ARRB1 interacts with SAGProteinHetionet hetionet:interacts:408-6295Inferred only
ARRB2 interacts with SAGProteinHetionet hetionet:interacts:409-6295Inferred only
RHO interacts with SAGProteinHetionet hetionet:interacts:6010-6295Inferred only
SAG participates in Activation of the phototransduction cascadePathwayReactome R-HSA-2485179Inferred only
SAG participates in Inactivation, recovery and regulation of the phototransduction cascadePathwayReactome R-HSA-2514859Inferred only
SAG participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
SAG participates in The phototransduction cascadePathwayReactome R-HSA-2514856Inferred only
SAG participates in Visual phototransductionPathwayReactome R-HSA-2187338Inferred only

Other names

4 names

Resolves to: SAG

Also called: 48 kDa proteinRetinal S-antigenRod photoreceptor arrestinS-AG

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