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Proteins/UNIPROT:Q8TDP1

RNASEH2C

Protein·UNIPROT:Q8TDP1

Open in the graph

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes..

Function from UniProtKB (Q8TDP1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

Aicardi-Goutieres syndrome has a germline basis in RNASEH2CDiseaseGenCC HGNC:24116|MONDO:0018866Inferred only
Aicardi-Goutieres syndrome 3 has a germline basis in RNASEH2CDiseaseGenCC HGNC:24116|MONDO:0012471Inferred only
RNASEH2C-related type 1 interferonopathy has a germline basis in RNASEH2CDiseaseGenCC HGNC:24116|MONDO:0700258Inferred only

Statements

4 statements

4 statements · 2 reference databases · Subject: RNASEH2C · Sources: Hetionet, WikiPathways

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BAG4 covaries with RNASEH2CProteinHetionet hetionet:covaries:84153-9530Inferred only
CCDC157 covaries with RNASEH2CProteinHetionet hetionet:covaries:550631-84153Inferred only
UBC interacts with RNASEH2CProteinHetionet hetionet:interacts:7316-84153Inferred only
RNASEH2C participates in Pathways of nucleic acid metabolism and innate immune sensingPathwayWikiPathways WP4705Inferred only

Other names

6 names

Resolves to: RNASEH2C

Also called: AGS3Aicardi-Goutieres syndrome 3 proteinAYP1Ribonuclease HI subunit CRNase H1 small subunitRNase H2 subunit C

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