Pathway
Pathways of nucleic acid metabolism and innate immune sensing
Cytosolic DNA and RNA can lead to innate immune sensing via three paths. DNA is sensed by cGAS, which activates STING. RNA is sensed by MDA5 and RIG-I, which activates MAVS. An activation of STING...
WP:4705
What the reference databases state
Statements
16 statements
16 statements · 1 reference database · Subject: Pathways of nucleic acid metabolism and innate immune sensing · Sources: WikiPathways
- ADAR participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- CGAS participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- IFIH1 participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- IFNB1 participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- IRF3 participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- MAVS participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- OAS1 participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- RIGI participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- RNASEH2A participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- RNASEH2B participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- RNASEH2C participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- RNASEL participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
Show the remaining 4
- RNASET2 participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- SAMHD1 participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- STING1 participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only
- TREX1 participates in Pathways of nucleic acid metabolism and innate immune sensingProteinWikiPathways WP4705Inferred only