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Proteins/UNIPROT:O00287

RFXAP

Protein·UNIPROT:O00287

Open in the graph

Part of the RFX complex that binds to the X-box of MHC II promoters.

Function from UniProtKB (O00287), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

MHC class II deficiency has a germline basis in RFXAPDiseaseGenCC HGNC:9988|MONDO:0008855Inferred only
MHC class II deficiency 4 has a germline basis in RFXAPDiseaseGenCC HGNC:9988|MONDO:0971015Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: RFXAP · Sources: gene ontology, Hetionet

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EPS8 interacts with RFXAPProteinHetionet hetionet:interacts:2059-5994Inferred only
RFXAP interacts with HDAC4ProteinHetionet hetionet:interacts:5994-9759Inferred only
RFX5 interacts with RFXAPProteinHetionet hetionet:interacts:5993-5994Inferred only
RFXAP interacts with RFXANKProteinHetionet hetionet:interacts:5994-8625Inferred only
RFXAP interacts with SMARCA4ProteinHetionet hetionet:interacts:5994-6597Inferred only
RFXAP regulates positive regulation of MHC class II biosynthetic processBiological processgene ontology O00287|GO:0045348Inferred only
RFXAP regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology O00287|GO:0045944Inferred only
RFXAP regulates regulation of transcription by RNA polymerase IIBiological processgene ontology O00287|GO:0006357Inferred only

Other names

2 names

Resolves to: RFXAP

Also called: RFX DNA-binding complex 36 kDa subunitRFX-associated protein

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