Proteins/UNIPROT:Q2KHR2

RFX7

ProteinUNIPROT:Q2KHR2

Transcription factor. Acts as a transcriptional activator by binding to promoter regions of target genes, such as PDCD4, PIK3IP1, MXD4, PNRC1, and RFX5. Plays a role in natural killer (NK) cell maintenance and immunity. May play a role in the process of ciliogenesis in the neural tube and neural tube closure (By similarity)..

Function from UniProtKB (Q2KHR2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

complex neurodevelopmental disorder has a germline basis in RFX7DiseaseGenCC HGNC:25777|MONDO:0100038Inferred only
intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities has a germline basis in RFX7DiseaseGenCC HGNC:25777|MONDO:0957228Inferred only

Statements

10 statements

10 statements · 3 reference databases · Subject: RFX7 · Sources: gene ontology, Hetionet, WikiPathways

Order

RFX7 covaries with ANKRD40ProteinHetionet hetionet:covaries:64864-91369Inferred only
ASPDH covaries with RFX7ProteinHetionet hetionet:covaries:554235-64864Inferred only
RFX7 covaries with DDX39AProteinHetionet hetionet:covaries:10212-64864Inferred only
RFX7 covaries with DENND4AProteinHetionet hetionet:covaries:10260-64864Inferred only
RFX7 covaries with JRKLProteinHetionet hetionet:covaries:64864-8690Inferred only
RFX7 covaries with TBX5ProteinHetionet hetionet:covaries:64864-6910Inferred only
RFX7 covaries with ZNF699ProteinHetionet hetionet:covaries:374879-64864Inferred only
RFX7 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
RFX7 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q2KHR2|GO:0045944Inferred only
RFX7 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q2KHR2|GO:0006357Inferred only

Other names

3 names

Resolves to: RFX7

Also called: Regulatory factor X 7Regulatory factor X domain-containing protein 2RFXDC2

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