Proteins/UNIPROT:Q7Z3Z2

RD3

ProteinUNIPROT:Q7Z3Z2

Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2D and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that also plays an essential role for recycling GMP and indirectly, cGMP. Plays an important role for the survival of rods and cones in the retina (By similarity)..

Function from UniProtKB (Q7Z3Z2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

Leber congenital amaurosis has a germline basis in RD3DiseaseGenCC HGNC:19689|MONDO:0018998Inferred only
Leber congenital amaurosis 12 has a germline basis in RD3DiseaseGenCC HGNC:19689|MONDO:0012525Inferred only
RD3-related retinopathy has a germline basis in RD3DiseaseGenCC HGNC:19689|MONDO:0700235Inferred only

Statements

5 statements

5 statements · 2 reference databases · Subject: RD3 · Sources: gene ontology, Hetionet

Order

BCR covaries with RD3ProteinHetionet hetionet:covaries:343035-613Inferred only
DACH2 covaries with RD3ProteinHetionet hetionet:covaries:117154-343035Inferred only
SLC16A6 covaries with RD3ProteinHetionet hetionet:covaries:343035-9120Inferred only
APP interacts with RD3ProteinHetionet hetionet:interacts:343035-351Inferred only
RD3 regulates negative regulation of guanylate cyclase activityBiological processgene ontology Q7Z3Z2|GO:0031283Inferred only

Other names

3 names

Resolves to: RD3

Also called: C1orf36Protein RD3Retinal degeneration protein 3

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