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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q8WZA2

RAPGEF4

Protein·UNIPROT:Q8WZA2

Open in the graph

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Does not seem to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity)..

Function from UniProtKB (Q8WZA2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

25 statements

25 statements · 4 reference databases · Subject: RAPGEF4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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RAPGEF4 covaries with PALS1ProteinHetionet hetionet:covaries:11069-64398Inferred only
ABCC8 interacts with RAPGEF4ProteinHetionet hetionet:interacts:11069-6833Inferred only
ATXN1 interacts with RAPGEF4ProteinHetionet hetionet:interacts:11069-6310Inferred only
MAP1A interacts with RAPGEF4ProteinHetionet hetionet:interacts:11069-4130Inferred only
RAP1A interacts with RAPGEF4ProteinHetionet hetionet:interacts:11069-5906Inferred only
RAP2A interacts with RAPGEF4ProteinHetionet hetionet:interacts:11069-5911Inferred only
RIMS2 interacts with RAPGEF4ProteinHetionet hetionet:interacts:11069-9699Inferred only
RAPGEF4 interacts with RRAS2ProteinHetionet hetionet:interacts:11069-22800Inferred only
RAPGEF4 participates in 16p13 11 copy number variation syndrome PathwayWikiPathways WP5502Inferred only
RAPGEF4 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
RAPGEF4 participates in Glucagon-like Peptide-1 (GLP1) regulates insulin secretionPathwayReactome R-HSA-381676Inferred only
RAPGEF4 participates in HemostasisPathwayReactome R-HSA-109582Inferred only

Show the remaining 13

RAPGEF4 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
RAPGEF4 participates in Integration of energy metabolismPathwayReactome R-HSA-163685Inferred only
RAPGEF4 participates in Integrin signalingPathwayReactome R-HSA-354192Inferred only
RAPGEF4 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
RAPGEF4 participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
RAPGEF4 participates in Platelet Aggregation (Plug Formation)PathwayReactome R-HSA-76009Inferred only
RAPGEF4 participates in Rap1 signallingPathwayReactome R-HSA-392517Inferred only
RAPGEF4 participates in Regulation of insulin secretionPathwayReactome R-HSA-422356Inferred only
RAPGEF4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
RAPGEF4 regulates positive regulation of insulin secretionBiological processgene ontology Q8WZA2|GO:0032024Inferred only
RAPGEF4 regulates regulation of synaptic vesicle cycleBiological processgene ontology Q8WZA2|GO:0098693Inferred only
RAPGEF4 decreases the expression of CHMP4AProteinHetionet hetionet:regulates:11069-29082Inferred only
RAPGEF4 decreases the expression of TLE1ProteinHetionet hetionet:regulates:11069-7088Inferred only

Other names

7 names

Resolves to: RAPGEF4

Also called: cAMP-GEFIIcAMP-regulated guanine nucleotide exchange factor IICGEF2EPAC 2EPAC2Exchange factor directly activated by cAMP 2Exchange protein directly activated by cAMP 2

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