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Proteins/UNIPROT:O60542

PSPN

Protein·UNIPROT:O60542

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Growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor..

Function from UniProtKB (O60542), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

12 statements

12 statements · 2 reference databases · Subject: PSPN · Sources: Hetionet, Reactome

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PSPN covaries with BCLAF3ProteinHetionet hetionet:covaries:256643-5623Inferred only
PSPN interacts with GFRA4ProteinHetionet hetionet:interacts:5623-64096Inferred only
PSPN participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
PSPN participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
PSPN participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
PSPN participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
PSPN participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
PSPN participates in NCAM1 interactionsPathwayReactome R-HSA-419037Inferred only
PSPN participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
PSPN participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
PSPN participates in RET signalingPathwayReactome R-HSA-8853659Inferred only
PSPN participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Other names

2 names

Resolves to: PSPN

Also called: PersephinPSP

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