Proteins/UNIPROT:Q9GZZ7

GFRA4

ProteinUNIPROT:Q9GZZ7

Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla..

Function from UniProtKB (Q9GZZ7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 2 reference databases · Subject: GFRA4 · Sources: Hetionet, Reactome

Order

PSPN interacts with GFRA4ProteinHetionet hetionet:interacts:5623-64096Inferred only
GFRA4 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
GFRA4 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
GFRA4 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
GFRA4 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
GFRA4 participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
GFRA4 participates in NCAM1 interactionsPathwayReactome R-HSA-419037Inferred only
GFRA4 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
GFRA4 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
GFRA4 participates in RET signalingPathwayReactome R-HSA-8853659Inferred only
GFRA4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Other names

4 names

Resolves to: GFRA4

Also called: GDNF receptor alpha-4GDNFR-alpha-4GFR-alpha-4Persephin receptor

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