Proteins/UNIPROT:Q9GZV8

PRDM14

ProteinUNIPROT:Q9GZV8

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'..

Function from UniProtKB (Q9GZV8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

12 statements

12 statements · 4 reference databases · Subject: PRDM14 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

PRDM14 covaries with ARTNProteinHetionet hetionet:covaries:63978-9048Inferred only
PRDM14 interacts with ATPAF2ProteinHetionet hetionet:interacts:63978-91647Inferred only
CBFA2T2 interacts with PRDM14ProteinHetionet hetionet:interacts:63978-9139Inferred only
PRDM14 interacts with HEXIM2ProteinHetionet hetionet:interacts:124790-63978Inferred only
ID3 interacts with PRDM14ProteinHetionet hetionet:interacts:3399-63978Inferred only
RUNX1T1 interacts with PRDM14ProteinHetionet hetionet:interacts:63978-862Inferred only
PRDM14 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
PRDM14 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
PRDM14 participates in Transcriptional regulation of pluripotent stem cellsPathwayReactome R-HSA-452723Inferred only
PRDM14 regulates positive regulation of flagellated sperm motilityBiological processgene ontology Q9GZV8|GO:1902093Inferred only
PRDM14 regulates positive regulation of stem cell population maintenanceBiological processgene ontology Q9GZV8|GO:1902459Inferred only
PRDM14 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9GZV8|GO:0006357Inferred only

Other names

1 name

Resolves to: PRDM14

Also called: PR domain-containing protein 14

← Every protein Find it in the graph →