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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q5T4W7

ARTN

Protein·UNIPROT:Q5T4W7

Open in the graph

Growth factor that supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Acts by binding to its coreceptor, GFRA3, leading to autophosphorylation and activation of the RET receptor. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity)..

Function from UniProtKB (Q5T4W7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

14 statements

14 statements · 2 reference databases · Subject: ARTN · Sources: Hetionet, Reactome

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MPEG1 covaries with ARTNProteinHetionet hetionet:covaries:219972-9048Inferred only
PRDM14 covaries with ARTNProteinHetionet hetionet:covaries:63978-9048Inferred only
RPIA covaries with ARTNProteinHetionet hetionet:covaries:22934-9048Inferred only
GFRA3 interacts with ARTNProteinHetionet hetionet:interacts:2676-9048Inferred only
ARTN participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
ARTN participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
ARTN participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
ARTN participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
ARTN participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
ARTN participates in NCAM1 interactionsPathwayReactome R-HSA-419037Inferred only
ARTN participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
ARTN participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only

Show the remaining 2

ARTN participates in RET signalingPathwayReactome R-HSA-8853659Inferred only
ARTN participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Other names

3 names

Resolves to: ARTN

Also called: EnovinEVNNeublastin

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