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Proteins/UNIPROT:Q03052

POU3F1

Protein·UNIPROT:Q03052

Open in the graph

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (By similarity)..

Function from UniProtKB (Q03052), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

12 statements

12 statements · 4 reference databases · Subject: POU3F1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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HMGA1 interacts with POU3F1ProteinHetionet hetionet:interacts:3159-5453Inferred only
HMGB2 interacts with POU3F1ProteinHetionet hetionet:interacts:3148-5453Inferred only
POU3F1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
POU3F1 participates in EGR2 and SOX10-mediated initiation of Schwann cell myelinationPathwayReactome R-HSA-9619665Inferred only
POU3F1 participates in Formation of the anterior neural platePathwayReactome R-HSA-9823739Inferred only
POU3F1 participates in Formation of the posterior neural platePathwayReactome R-HSA-9832991Inferred only
POU3F1 participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
POU3F1 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
POU3F1 participates in SOX genes and their influence on neurogenesis and neurodevelopmental disordersPathwayWikiPathways WP5568Inferred only
POU3F1 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology Q03052|GO:0045893Inferred only
POU3F1 regulates positive regulation of gene expressionBiological processgene ontology Q03052|GO:0010628Inferred only
POU3F1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q03052|GO:0006357Inferred only

Other names

7 names

Resolves to: POU3F1

Also called: Oct-6OCT6Octamer-binding protein 6Octamer-binding transcription factor 6OTF-6OTF6POU domain transcription factor SCIP

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