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Proteins/UNIPROT:Q6UW63
Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway..
Function from UniProtKB (Q6UW63), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
9 statements
9 statements · 2 reference databases · Subject: POGLUT2 · Sources: Hetionet, Rhea
2 reactions
L-seryl-[EGF-like domain protein]+UDP-alpha-D-glucose3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein]+UDP+hydron
Catalysed by POGLUT2 or POGLUT3 or POGLUT1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:58116CC BY 4.0Reference data
L-seryl-[EGF-like domain protein]+UDP-alpha-D-xylose3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein]+UDP+hydron
8 names
Resolves to: POGLUT2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:62016CC BY 4.0Reference data