Proteins/UNIPROT:Q96FM1

PGAP3

ProteinUNIPROT:Q96FM1GPI-specific phospholipase A2-like PGAP3

Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the first step of the fatty acid remodeling, by removing the unsaturated acyl chain at sn-2 of inositol phosphate, generating a lyso-GPI intermediate (Probable). The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts (By similarity)..

Function from UniProtKB (Q96FM1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

hyperphosphatasia with intellectual disability syndrome 4 has a germline basis in PGAP3DiseaseGenCC HGNC:23719|MONDO:0014318Inferred only
hyperphosphatasia-intellectual disability syndrome has a germline basis in PGAP3DiseaseGenCC HGNC:23719|MONDO:0016596Inferred only

Statements

5 statements

5 statements · 3 reference databases · Subject: PGAP3 · Sources: Bgee, Hetionet, WikiPathways

Order

PGAP3 is expressed in pancreatic ductal cellCell typeBgee ENSG00000161395Inferred only
PGAP3 participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only
PGAP3 participates in Glycosylphosphatidyl inositol anchor pathwayPathwayWikiPathways WP5505Inferred only
ENOSF1 increases the expression of PGAP3ProteinHetionet hetionet:regulates:55556-93210Inferred only
SKIC2 increases the expression of PGAP3ProteinHetionet hetionet:regulates:6499-93210Inferred only

Reactions

1 reaction

[protein]-C-terminal carboxyl phosphoethanolamide-GPI(deacylinositol-H7)+water[protein]-C-terminal carboxyl phosphoethanolamide-lysoGPI(deacylinositol-H7)+a fatty acid+hydron
Catalysed by PGAP3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:83847CC BY 4.0Reference data

Other names

7 names

Resolves to: PGAP3

Also called: CAB2COS16 homologGene coamplified with ERBB2 proteinhCOS16PER1-like domain-containing protein 1PERLD1Post-GPI attachment to proteins factor 3

← Every protein Find it in the graph →