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Proteins/UNIPROT:Q9H4Z3
Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally..
Function from UniProtKB (Q9H4Z3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
50 statements
50 statements · 3 reference databases · Subject: PCIF1 · Sources: gene ontology, Hetionet, Human Protein Atlas
1 reaction
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA+S-adenosyl-L-methioninea 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA+S-adenosyl-L-homocysteine+hydron
Catalysed by PCIF1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22744CC BY 4.0Reference data
10 names
Resolves to: PCIF1