Proteins/UNIPROT:Q9HBI1

PARVB

ProteinUNIPROT:Q9HBI1

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration..

Function from UniProtKB (Q9HBI1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 3 reference databases · Subject: PARVB · Sources: Hetionet, Reactome, WikiPathways

Order

PARVB covaries with COMPProteinHetionet hetionet:covaries:1311-29780Inferred only
PARVB covaries with MRGBPProteinHetionet hetionet:covaries:29780-55257Inferred only
PARVB covaries with NSMCE3ProteinHetionet hetionet:covaries:29780-56160Inferred only
PARVB covaries with RHBDL1ProteinHetionet hetionet:covaries:29780-9028Inferred only
PARVB covaries with SRMProteinHetionet hetionet:covaries:29780-6723Inferred only
TNNI1 covaries with PARVBProteinHetionet hetionet:covaries:29780-7135Inferred only
TSPAN17 covaries with PARVBProteinHetionet hetionet:covaries:26262-29780Inferred only
PARVB covaries with ZNF774ProteinHetionet hetionet:covaries:29780-342132Inferred only
ZYX covaries with PARVBProteinHetionet hetionet:covaries:29780-7791Inferred only
ARHGEF6 interacts with PARVBProteinHetionet hetionet:interacts:29780-9459Inferred only
ILK interacts with PARVBProteinHetionet hetionet:interacts:29780-3611Inferred only
UBC interacts with PARVBProteinHetionet hetionet:interacts:29780-7316Inferred only

Show the remaining 8

PARVB participates in Cell junction organizationPathwayReactome R-HSA-446728Inferred only
PARVB participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
PARVB participates in Cell-extracellular matrix interactionsPathwayReactome R-HSA-446353Inferred only
PARVB participates in Focal adhesionPathwayWikiPathways WP306Inferred only
PARVB participates in Regulation of cytoskeletal remodeling and cell spreading by IPP complex componentsPathwayReactome R-HSA-446388Inferred only
ARNT2 increases the expression of PARVBProteinHetionet hetionet:regulates:9915-29780Inferred only
GSTZ1 increases the expression of PARVBProteinHetionet hetionet:regulates:2954-29780Inferred only
TP53 decreases the expression of PARVBProteinHetionet hetionet:regulates:7157-29780Inferred only

Other names

2 names

Resolves to: PARVB

Also called: AffixinBeta-parvin

← Every protein Find it in the graph →