Proteins/UNIPROT:Q8TAK6

OLIG1

ProteinUNIPROT:Q8TAK6

Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity)..

Function from UniProtKB (Q8TAK6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

22 statements

22 statements · 3 reference databases · Subject: OLIG1 · Sources: gene ontology, Hetionet, WikiPathways

Order

OLIG1 covaries with ESRRAProteinHetionet hetionet:covaries:116448-2101Inferred only
OLIG1 covaries with FBXO46ProteinHetionet hetionet:covaries:116448-23403Inferred only
OLIG1 covaries with FKBP8ProteinHetionet hetionet:covaries:116448-23770Inferred only
OLIG1 covaries with GPR137CProteinHetionet hetionet:covaries:116448-283554Inferred only
NPY5R covaries with OLIG1ProteinHetionet hetionet:covaries:116448-4889Inferred only
PGRMC2 covaries with OLIG1ProteinHetionet hetionet:covaries:10424-116448Inferred only
OLIG1 covaries with PRRT2ProteinHetionet hetionet:covaries:112476-116448Inferred only
RNF7 covaries with OLIG1ProteinHetionet hetionet:covaries:116448-9616Inferred only
RRAGA covaries with OLIG1ProteinHetionet hetionet:covaries:10670-116448Inferred only
OLIG1 covaries with TAF12ProteinHetionet hetionet:covaries:116448-6883Inferred only
OLIG1 covaries with TMEM200BProteinHetionet hetionet:covaries:116448-399474Inferred only
OLIG1 covaries with TMX4ProteinHetionet hetionet:covaries:116448-56255Inferred only

Show the remaining 10

ZNF660 covaries with OLIG1ProteinHetionet hetionet:covaries:116448-285349Inferred only
CACNA1A interacts with OLIG1ProteinHetionet hetionet:interacts:116448-773Inferred only
MRPL12 interacts with OLIG1ProteinHetionet hetionet:interacts:116448-6182Inferred only
PSMD14 interacts with OLIG1ProteinHetionet hetionet:interacts:10213-116448Inferred only
SMAD2 interacts with OLIG1ProteinHetionet hetionet:interacts:116448-4087Inferred only
OLIG1 participates in Integrative Analysis of Treg Glial Interactions PathwayWikiPathways WP5561Inferred only
OLIG1 participates in Neural crest differentiationPathwayWikiPathways WP2064Inferred only
OLIG1 participates in Oligodendrocyte developmentPathwayWikiPathways WP5574Inferred only
OLIG1 participates in Oligodendrocyte specification and differentiation leading to myelin components for CNSPathwayWikiPathways WP4304Inferred only
OLIG1 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q8TAK6|GO:0045944Inferred only

Other names

5 names

Resolves to: OLIG1

Also called: BHLHB6BHLHE21Class B basic helix-loop-helix protein 6Class E basic helix-loop-helix protein 21Oligo1

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