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Proteins/UNIPROT:Q5VVY1
Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro). May activate NTMT1 by priming its substrates for trimethylation..
Function from UniProtKB (Q5VVY1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 statements
3 statements · 1 reference database · Subject: NTMT2 · Sources: Hetionet
3 reactions
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein]+S-adenosyl-L-methionineN-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein]+S-adenosyl-L-homocysteine+hydron
Catalysed by NTMT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54096CC BY 4.0Reference data
N-terminal L-prolyl-L-prolyl-L-lysyl-[protein]+S-adenosyl-L-methionineN-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein]+S-adenosyl-L-homocysteine+hydron
Catalysed by NTMT2
7 names
Resolves to: NTMT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54100CC BY 4.0Reference data
N-terminal L-seryl-L-prolyl-L-lysyl-[protein]+S-adenosyl-L-methionineN-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein]+S-adenosyl-L-homocysteine+hydron
Catalysed by NTMT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54104CC BY 4.0Reference data