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Proteins/UNIPROT:Q9GZQ6

NPFFR1

Protein·UNIPROT:Q9GZQ6

Open in the graph

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system..

Function from UniProtKB (Q9GZQ6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 3 reference databases · Subject: NPFFR1 · Sources: Hetionet, Reactome, WikiPathways

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NPFF interacts with NPFFR1ProteinHetionet hetionet:interacts:64106-8620Inferred only
NPFFR1 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
NPFFR1 participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
NPFFR1 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
NPFFR1 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
NPFFR1 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
NPFFR1 participates in Orexin and neuropeptides FF and QRFP bind to their respective receptorsPathwayReactome R-HSA-389397Inferred only
NPFFR1 participates in Orexin receptor pathwayPathwayWikiPathways WP5094Inferred only
NPFFR1 participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
NPFFR1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
NPFFR1 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Other names

4 names

Resolves to: NPFFR1

Also called: G protein-coupled receptor 147GPR147NPFF1RFamide-related peptide receptor OT7T022

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