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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:O15130

NPFF

Protein·UNIPROT:O15130

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Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels..

Function from UniProtKB (O15130), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

16 statements

16 statements · 3 reference databases · Subject: NPFF · Sources: gene ontology, Hetionet, Reactome

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NPFF interacts with NPFFR1ProteinHetionet hetionet:interacts:64106-8620Inferred only
NPFF interacts with NPFFR2ProteinHetionet hetionet:interacts:10886-8620Inferred only
NPFF participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
NPFF participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
NPFF participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
NPFF participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
NPFF participates in Orexin and neuropeptides FF and QRFP bind to their respective receptorsPathwayReactome R-HSA-389397Inferred only
NPFF participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
NPFF participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
NPFF participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
NPFF regulates negative regulation of appetiteBiological processgene ontology O15130|GO:0032099Inferred only
NPFF regulates negative regulation of heart rateBiological processgene ontology O15130|GO:0010459Inferred only

Show the remaining 4

NPFF regulates negative regulation of insulin secretionBiological processgene ontology O15130|GO:0046676Inferred only
NPFF regulates positive regulation of blood pressureBiological processgene ontology O15130|GO:0045777Inferred only
NPFF regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology O15130|GO:0007204Inferred only
NPFF regulates regulation of membrane depolarizationBiological processgene ontology O15130|GO:0003254Inferred only

Other names

4 names

Resolves to: NPFF

Also called: ; Neuropeptide AFFMRFamide-related peptidesNPAFNPSF

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