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Proteins/UNIPROT:Q13253

NOG

Protein·UNIPROT:Q13253

Open in the graph

Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6..

Function from UniProtKB (Q13253), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

7 rows

brachydactyly type B2 has a germline basis in NOGDiseaseGenCC HGNC:7866|MONDO:0012658Inferred only
multiple synostoses syndrome has a germline basis in NOGDiseaseGenCC HGNC:7866|MONDO:0017923Inferred only
multiple synostoses syndrome 1 has a germline basis in NOGDiseaseGenCC HGNC:7866|MONDO:0008519Inferred only
NOG-related symphalangism spectrum disorder has a germline basis in NOGDiseaseGenCC HGNC:7866|MONDO:0100521Inferred only
proximal symphalangism has a germline basis in NOGDiseaseGenCC HGNC:7866|MONDO:0008511Inferred only
stapes ankylosis with broad thumbs and toes has a germline basis in NOGDiseaseGenCC HGNC:7866|MONDO:0008484Inferred only
tarsal-carpal coalition syndrome has a germline basis in NOGDiseaseGenCC HGNC:7866|MONDO:0008521Inferred only

Statements

36 statements

36 statements · 4 reference databases · Subject: NOG · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

NOG covaries with C4BPAProteinHetionet hetionet:covaries:722-9241Inferred only
NOG covaries with CNIH3ProteinHetionet hetionet:covaries:149111-9241Inferred only
NOG covaries with TMEM132BProteinHetionet hetionet:covaries:114795-9241Inferred only
BMP2 interacts with NOGProteinHetionet hetionet:interacts:650-9241Inferred only
BMP4 interacts with NOGProteinHetionet hetionet:interacts:652-9241Inferred only
BMP5 interacts with NOGProteinHetionet hetionet:interacts:653-9241Inferred only
BMP7 interacts with NOGProteinHetionet hetionet:interacts:655-9241Inferred only
NOG participates in 10q11 21q11 23 copy number variation syndromePathwayWikiPathways WP5352Inferred only
NOG participates in Bone morphogenic protein signaling and regulationPathwayWikiPathways WP1425Inferred only
NOG participates in Cardiac progenitor differentiationPathwayWikiPathways WP2406Inferred only
NOG participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
NOG participates in Embryonic stem cell pluripotency pathwaysPathwayWikiPathways WP3931Inferred only

Show the remaining 24

NOG participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
NOG participates in Formation of paraxial mesodermPathwayReactome R-HSA-9793380Inferred only
NOG participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
NOG participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
NOG participates in Pluripotent stem cell differentiation pathwayPathwayWikiPathways WP2848Inferred only
NOG participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
NOG participates in Signaling by BMPPathwayReactome R-HSA-201451Inferred only
NOG participates in Signaling by TGFB family membersPathwayReactome R-HSA-9006936Inferred only
NOG participates in TGF beta receptor signalingPathwayWikiPathways WP560Inferred only
NOG participates in TGF beta receptor signaling in skeletal dysplasiasPathwayWikiPathways WP4816Inferred only
NOG regulates negative regulation of astrocyte differentiationBiological processgene ontology Q13253|GO:0048712Inferred only
NOG regulates negative regulation of BMP signaling pathwayBiological processgene ontology Q13253|GO:0030514Inferred only
NOG regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q13253|GO:0090090Inferred only
NOG regulates negative regulation of cardiac epithelial to mesenchymal transitionBiological processgene ontology Q13253|GO:0062044Inferred only
NOG regulates negative regulation of cardiac muscle cell proliferationBiological processgene ontology Q13253|GO:0060044Inferred only
NOG regulates negative regulation of cell migrationBiological processgene ontology Q13253|GO:0030336Inferred only
NOG regulates negative regulation of osteoblast differentiationBiological processgene ontology Q13253|GO:0045668Inferred only
NOG regulates negative regulation of SMAD protein signal transductionBiological processgene ontology Q13253|GO:0060392Inferred only
NOG regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q13253|GO:0000122Inferred only
NOG regulates positive regulation of branching involved in ureteric bud morphogenesisBiological processgene ontology Q13253|GO:0090190Inferred only
NOG regulates positive regulation of gene expressionBiological processgene ontology Q13253|GO:0010628Inferred only
NOG regulates positive regulation of glomerulus developmentBiological processgene ontology Q13253|GO:0090193Inferred only
NOG regulates regulation of fibroblast growth factor receptor signaling pathwayBiological processgene ontology Q13253|GO:0040036Inferred only
NOG regulates regulation of neuronal synaptic plasticityBiological processgene ontology Q13253|GO:0048168Inferred only

Other names

1 name

Resolves to: NOG

Also called: Noggin

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