Proteins/UNIPROT:Q8NG66

NEK11

ProteinUNIPROT:Q8NG66

Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation..

Function from UniProtKB (Q8NG66), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 4 reference databases · Subject: NEK11 · Sources: gene ontology, Hetionet, Reactome, UniProt

Order

HMGN3 covaries with NEK11ProteinHetionet hetionet:covaries:79858-9324Inferred only
STK38 covaries with NEK11ProteinHetionet hetionet:covaries:11329-79858Inferred only
APP interacts with NEK11ProteinHetionet hetionet:interacts:351-79858Inferred only
HSP90AA1 interacts with NEK11ProteinHetionet hetionet:interacts:3320-79858Inferred only
HSP90AB1 interacts with NEK11ProteinHetionet hetionet:interacts:3326-79858Inferred only
MYC interacts with NEK11ProteinHetionet hetionet:interacts:4609-79858Inferred only
NEK2 interacts with NEK11ProteinHetionet hetionet:interacts:4751-79858Inferred only
NEK11 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
NEK11 participates in Cell Cycle CheckpointsPathwayReactome R-HSA-69620Inferred only
NEK11 participates in G1/S DNA Damage CheckpointsPathwayReactome R-HSA-69615Inferred only
NEK11 participates in p53-Independent G1/S DNA Damage CheckpointPathwayReactome R-HSA-69613Inferred only
NEK11 participates in Ubiquitin-Mediated Degradation of Phosphorylated Cdc25APathwayReactome R-HSA-69601Inferred only

Show the remaining 6

NEK11 regulates regulation of mitotic cell cycle phase transitionBiological processgene ontology Q8NG66|GO:1901990Inferred only
NEK11 decreases the expression of CDKN1BProteinHetionet hetionet:regulates:79858-1027Inferred only
NEK11 decreases the expression of HAT1ProteinHetionet hetionet:regulates:79858-8520Inferred only
NEK11 increases the expression of RBKSProteinHetionet hetionet:regulates:79858-64080Inferred only
NEK11 requires the cofactor magnesium(2+)CompoundUniProt Q8NG66Inferred only
NEK11 requires the cofactor Mn(2+)CompoundUniProt Q8NG66Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

2 names

Resolves to: NEK11

Also called: Never in mitosis A-related kinase 11NimA-related protein kinase 11

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