Proteins/UNIPROT:Q6ZWH5

NEK10

ProteinUNIPROT:Q6ZWH5

Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport..

Function from UniProtKB (Q6ZWH5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

ciliary dyskinesia, primary, 44 has a germline basis in NEK10DiseaseGenCC HGNC:18592|MONDO:0032914Inferred only
primary ciliary dyskinesia has a germline basis in NEK10DiseaseGenCC HGNC:18592|MONDO:0016575Inferred only

Statements

16 statements

16 statements · 3 reference databases · Subject: NEK10 · Sources: gene ontology, Hetionet, UniProt

Order

SUMO1 interacts with NEK10ProteinHetionet hetionet:interacts:152110-7341Inferred only
UBC interacts with NEK10ProteinHetionet hetionet:interacts:152110-7316Inferred only
NEK10 regulates positive regulation of MAP kinase activityBiological processgene ontology Q6ZWH5|GO:0043406Inferred only
NEK10 regulates positive regulation of protein autophosphorylationBiological processgene ontology Q6ZWH5|GO:0031954Inferred only
NEK10 regulates regulation of cell cycle G2/M phase transitionBiological processgene ontology Q6ZWH5|GO:1902749Inferred only
NEK10 regulates regulation of ERK1 and ERK2 cascadeBiological processgene ontology Q6ZWH5|GO:0070372Inferred only
NEK10 increases the expression of GPX3ProteinHetionet hetionet:regulates:152110-2878Inferred only
NEK10 increases the expression of LCN2ProteinHetionet hetionet:regulates:152110-3934Inferred only
NEK10 increases the expression of MYLKProteinHetionet hetionet:regulates:152110-4638Inferred only
NEK10 decreases the expression of SMNDC1ProteinHetionet hetionet:regulates:152110-10285Inferred only
NEK10 decreases the expression of SPON2ProteinHetionet hetionet:regulates:152110-10417Inferred only
NEK10 increases the expression of SYNGR3ProteinHetionet hetionet:regulates:152110-9143Inferred only

Show the remaining 4

NEK10 decreases the expression of TMSB15AProteinHetionet hetionet:regulates:152110-11013Inferred only
NEK10 increases the expression of WIF1ProteinHetionet hetionet:regulates:152110-11197Inferred only
NEK10 decreases the expression of ZW10ProteinHetionet hetionet:regulates:152110-9183Inferred only
NEK10 requires the cofactor magnesium(2+)CompoundUniProt Q6ZWH5Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

2 names

Resolves to: NEK10

Also called: Never in mitosis A-related kinase 10NimA-related protein kinase 10

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