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Proteins/UNIPROT:Q8NI08
Transcriptional coactivator which enhances the transcriptional activities of several nuclear receptors including ESR1, THRB, PPARG and RARA. Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex. Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Required to stabilize V-ATPase V1 subunits ATP6V1B2 and ATP6V1A at membrane sites (By similarity). Involved in protection against oxidative damage. Involved in urine acidification (By similarity)..
[Isoform 1]: Exhibits oxidation resistance activity. Protects neuronal cells from oxidative stress with weaker neuroprotective activity than isoform 5 (By similarity)..
[Isoform 5]: Exhibits oxidation resistance activity. Protects neuronal cells from oxidative stress with stronger neuroprotective activity than isoform 1 (By similarity). Inhibits endosome-mediated viral entry by inhibiting fusion of the viral and endosomal membranes and subsequent nuclear translocation of viral ribonucleoproteins. Promotes increased cytoplasmic vesicular acidification, lysosomal protease activity and the degradation of endocytosed material..
Function from UniProtKB (Q8NI08), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
15 statements
15 statements · 3 reference databases · Subject: NCOA7 · Sources: gene ontology, Hetionet, WikiPathways
4 names
Resolves to: NCOA7