Proteins/UNIPROT:P11836

MS4A1

ProteinUNIPROT:P11836

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR..

Function from UniProtKB (P11836), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

immunodeficiency, common variable, 5 has a germline basis in MS4A1DiseaseGenCC HGNC:7315|MONDO:0013285Inferred only

Statements

13 statements

13 statements · 3 reference databases · Subject: MS4A1 · Sources: gene ontology, Hetionet, WikiPathways

Order

DAND5 covaries with MS4A1ProteinHetionet hetionet:covaries:199699-931Inferred only
OR1M1 covaries with MS4A1ProteinHetionet hetionet:covaries:125963-931Inferred only
MS4A1 interacts with CD40ProteinHetionet hetionet:interacts:931-958Inferred only
MS4A1 interacts with CSNK2A1ProteinHetionet hetionet:interacts:1457-931Inferred only
MS4A1 interacts with CSNK2A2ProteinHetionet hetionet:interacts:1459-931Inferred only
MS4A1 interacts with IRF4ProteinHetionet hetionet:interacts:3662-931Inferred only
MS4A1 interacts with LCKProteinHetionet hetionet:interacts:3932-931Inferred only
MS4A1 interacts with LYNProteinHetionet hetionet:interacts:4067-931Inferred only
MS4A1 participates in 11p11 2 copy number variation syndrome PathwayWikiPathways WP5348Inferred only
MS4A1 participates in Extrafollicular and follicular B cell activation by SARS CoV 2PathwayWikiPathways WP5218Inferred only
MS4A1 participates in Lupus therapiesPathwayWikiPathways WP5560Inferred only
MS4A1 participates in Multiple sclerosis mechanism and therapiesPathwayWikiPathways WP5540Inferred only

Show the remaining 1

MS4A1 regulates positive regulation of calcium ion import across plasma membraneBiological processgene ontology P11836|GO:1905665Inferred only

Other names

6 names

Resolves to: MS4A1

Also called: B-lymphocyte surface antigen B1Bp35CD antigen CD20CD20Leukocyte surface antigen Leu-16Membrane-spanning 4-domains subfamily A member 1

← Every protein Find it in the graph →