Proteins/UNIPROT:Q8N907

DAND5

ProteinUNIPROT:Q8N907

Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (By similarity). Antagonist of BMP and TGF-beta signaling. Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway (By similarity). Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance..

Function from UniProtKB (Q8N907), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: DAND5 · Sources: gene ontology, Hetionet, Reactome

Order

DAND5 covaries with DHX37ProteinHetionet hetionet:covaries:199699-57647Inferred only
DAND5 covaries with MS4A1ProteinHetionet hetionet:covaries:199699-931Inferred only
DAND5 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
DAND5 participates in Regulation of signaling by NODALPathwayReactome R-HSA-1433617Inferred only
DAND5 participates in Signaling by NODALPathwayReactome R-HSA-1181150Inferred only
DAND5 regulates negative regulation of BMP signaling pathwayBiological processgene ontology Q8N907|GO:0030514Inferred only
DAND5 regulates negative regulation of nodal signaling pathwayBiological processgene ontology Q8N907|GO:1900108Inferred only
DAND5 regulates negative regulation of transforming growth factor beta receptor signaling pathwayBiological processgene ontology Q8N907|GO:0030512Inferred only

Other names

9 names

Resolves to: DAND5

Also called: CER2Cerberus-like protein 2Cerl-2CKTSF1B3COCOCysteine knot superfamily 1, BMP antagonist 3GREM3Gremlin-3SP1

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