Proteins/UNIPROT:O95866

MPIG6B

ProteinUNIPROT:O95866

Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling. Appears to operate in a calcium-independent manner..

Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B..

Function from UniProtKB (O95866), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

thrombocytopenia, anemia, and myelofibrosis has a germline basis in MPIG6BDiseaseGenCC HGNC:13937|MONDO:0044316Inferred only

Statements

8 statements

8 statements · 3 reference databases · Subject: MPIG6B · Sources: gene ontology, Hetionet, Reactome

Order

MPIG6B covaries with MECP2ProteinHetionet hetionet:covaries:4204-80739Inferred only
MPIG6B covaries with SNU13ProteinHetionet hetionet:covaries:4809-80739Inferred only
PTPN11 interacts with MPIG6BProteinHetionet hetionet:interacts:5781-80739Inferred only
PTPN6 interacts with MPIG6BProteinHetionet hetionet:interacts:5777-80739Inferred only
MPIG6B participates in GPVI-mediated activation cascadePathwayReactome R-HSA-114604Inferred only
MPIG6B participates in HemostasisPathwayReactome R-HSA-109582Inferred only
MPIG6B participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
MPIG6B regulates negative regulation of signal transductionBiological processgene ontology O95866|GO:0009968Inferred only

Other names

5 names

Resolves to: MPIG6B

Also called: C6orf25G6BG6B-BMegakaryocyte and platelet inhibitory receptor G6bProtein G6b

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