Proteins/UNIPROT:Q9NPJ1

MKKS

ProteinUNIPROT:Q9NPJ1

Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis..

Function from UniProtKB (Q9NPJ1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

Bardet-Biedl syndrome has a germline basis in MKKSDiseaseGenCC HGNC:7108|MONDO:0015229Inferred only
Bardet-Biedl syndrome 6 has a germline basis in MKKSDiseaseGenCC HGNC:7108|MONDO:0011523Inferred only
ciliopathy has a germline basis in MKKSDiseaseGenCC HGNC:7108|MONDO:0005308Inferred only
McKusick-Kaufman syndrome has a germline basis in MKKSDiseaseGenCC HGNC:7108|MONDO:0009367Inferred only
MKKS-related ciliopathy has a germline basis in MKKSDiseaseGenCC HGNC:7108|MONDO:1040050Inferred only

Statements

16 statements

16 statements · 4 reference databases · Subject: MKKS · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

MKKS covaries with WASHC2CProteinHetionet hetionet:covaries:253725-8195Inferred only
APP interacts with MKKSProteinHetionet hetionet:interacts:351-8195Inferred only
PTN interacts with MKKSProteinHetionet hetionet:interacts:5764-8195Inferred only
MKKS participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
MKKS participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
MKKS participates in BBSome-mediated cargo-targeting to ciliumPathwayReactome R-HSA-5620922Inferred only
MKKS participates in Cargo trafficking to the periciliary membranePathwayReactome R-HSA-5620920Inferred only
MKKS participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
MKKS participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
MKKS participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
MKKS participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
MKKS regulates negative regulation of appetite by leptin-mediated signaling pathwayBiological processgene ontology Q9NPJ1|GO:0038108Inferred only

Show the remaining 4

MKKS regulates regulation of cilium beat frequency involved in ciliary motilityBiological processgene ontology Q9NPJ1|GO:0060296Inferred only
CHMP2A decreases the expression of MKKSProteinHetionet hetionet:regulates:27243-8195Inferred only
FAH decreases the expression of MKKSProteinHetionet hetionet:regulates:2184-8195Inferred only
GUK1 decreases the expression of MKKSProteinHetionet hetionet:regulates:2987-8195Inferred only

Other names

3 names

Resolves to: MKKS

Also called: Bardet-Biedl syndrome 6 proteinBBS6McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin

← Every protein Find it in the graph →