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Proteins/UNIPROT:Q96IZ6
S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite..
Function from UniProtKB (Q96IZ6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 statements
3 statements · 1 reference database · Subject: METTL2A · Sources: Hetionet
2 reactions
CHEBI:82748+S-adenosyl-L-methionineCHEBI:74894+S-adenosyl-L-homocysteine+hydron
Catalysed by METTL2B or METTL2A or METTL8
Reaction pageLeft to rightBalanced
Rhea RHEA:50960CC BY 4.0Reference data
CHEBI:82748+S-adenosyl-L-methionineCHEBI:74894+S-adenosyl-L-homocysteine+hydron
Catalysed by METTL2B
3 names
Resolves to: METTL2A
Reaction pageLeft to rightBalanced
Rhea RHEA:60912CC BY 4.0Reference data